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1. An All-in-One Solution: gako PM140

For pharmacists who are looking for a simple, fast,

and affordable solution for mixing, deaeration, and

melting, the gako PM140 is a revolutionary device

that combines those multiple functionalities to

standardize the compounding process, ensuring

safety, quality, and efficacy for compounded prepa-

rations while saving time and money for the pharma-

cy (Figure 1).

Moreover, it can be used on its own or in a combined

workflow with other compounding equipment, such

as the gako unguator* or other devices or molds re-

quired for the preparation of semi-solids or molded

and melted solids.

1.1. Mechanism of Action

Due to its ingenious mechanism, the preparation in-

side the PM jar (mixing jar) simultaneously spins and

rotates around an axis in opposite planetary motion

while keeping all the components at an angle of 40°.

This promotes a centrifugal force caused by the ro-

tational movement making particles in the mixture

move toward the edges of the PM jar. As a result, the

mixing process can be conducted in an enclosed

environment without blades (Figure 2), reducing the

number of items to be cleaned afterwards and ena-

Figure 1. gako PM140 device.

bling the pharmacist to mix and deaerate formulas

within a simple one-step process (a process in less

than 60 seconds). This centrifugal motion is accom-

panied by uniform and gradual heat release, facilitat-

ing the melting of substances such as suppository

bases, gelatin bases, or gelling agents in the prepa-

ration (a process that requires around 15 minutes de-

pending on the base).

For optimal results, we are continuously developing

suitable accessories including jars and dispensers

for the gako PM140 (see section 3. Accessories). The

PM jars and dispensers provide a closed environ-

ment to reduce microbial contamination and elimi-

nate spilling and spreading problems. They can be

used in negative pressure cabinets to prevent haz-

ardous drug exposure. The disposable ones that are

also used as primary packages, help avoiding mate-

rial loss that would otherwise occur during the trans-

fer step from the preparation cup into the package.

Figure 2. The working mechanism of gako PM140.

* The gako unguator is a product line of fully automatic, semi-automatic, and manual versions devices, designed for mixing and the homogenization of

semi-solid preparations (gels, creams, ointments, and suppositories) using blades.