AB Sciex 4000 QTRAP Manual Perangkat Keras - Halaman 5

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System Overview

The 4000 QTRAP

mass spectrometer, a Turbo V™ ion source, a computer, and the Analyst

software.

WARNING! If you need to move the system, contact an FSE to assist you. Risk of

personal injury or instrument damage

Note: Before you operate the instrument, make sure you have read the Safety Practices

guide.

The 4000 QTRAP

mass spectrometer designed specifically for quantitative and qualitative

applications.

The Q3 region can be operated as either a standard quadrupole mass

spectrometer, or as a linear ion trap mass spectrometer. The unique scan modes

of both configurations can be linked to provide more and higher quality data

than either technique alone.

The 4000 QTRAP

This application involves measurement of specific molecular weight compounds

(usually a drug or metabolite in urine or other bodily fluid) and their resulting

fragment ions for determining the exact quantity of the compound in the sample

of interest. Quantitation is performed using a standard curve of mass

spectrometer signal intensity for various known concentrations of the compound.

The signal in the test sample is compared to the standard curve to determine the

concentration.

The typical scan type used for this application in the 4000 QTRAP system (as well

as all triple quadrupole instruments) is MRM (Multiple Reaction Monitoring).

Document Number: D1000092200 B

system includes a hybrid triple quadrupole/LIT (linear ion trap)

system includes a hybrid triple quadrupole LIT (linear ion trap)

system is best suited to three specific applications:

•

Quantitative analysis of small molecules

•

Qualitative analysis of small molecules

•

Qualitative analysis of proteins and peptides